Refractory Idiopathic Immune Purpura in Children
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چکیده
A minority or children with idiopathic or immune thrombocytopenic purpura (ITP) have the rerractory chronic rorm with bleeding problems (stage III or IV). The aim or this article is to provide an update on the immunopathogenesis and management or children with bleeding and severe refractory lIP. The man~lgement of such patients. according to a st~lging guideline. is described. I{ecent ciinic~11 and I~lbor~ltory observ~ltions document the disturbed immune responses th~lt occur on v~lrious levels in chronic lIP. New therapeutic options ~'re directed tow~lrds illiluencing these immullopathllgenic mechanisms. Because lIP is not ~ldequ~ltely defined ~Ind has heterogeneous manil'est~ltions. tod~IY's man~lgement recommend~ltions ~lre I~lrgely opinion-based rather than evidence-based. In severe refr~'ctory childhood lIP. consensus between the treating physician and the patient has to be achieved on ~In individual basis. The ~,im is to m~lint~,in
منابع مشابه
Epidemiology of Idiopathic Thrombocytopenic Purpura in Children
Abstract Background Immune thrombocytopenic purpura (ITP) is a common autoimmune bleeding condition in children that is characterized by a decrease in the platelet count. The aims of this study were to define epidemiologic features of patients with primary ITP who were admitted to Mofid Children's Hospital, Tehran, Iran, in a 5-year period. Methods We retrospectively studied the records of ...
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متن کاملIdiopathic thrombocytopenic purpura.
Idiopathic thrombocytopenic purpura in children usually a self limiting disorder. It may follow a viral infection or immunisation and is caused by an inappropriate response of the immune system. About 20-30% of children will fail to remit over six months (chronic idiopathic thrombocytopenic purpura). This is more likely in older children, especially girls. The disease is reviewed with reference...
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تاریخ انتشار 2004